SINTEZA UNOR DERIVAȚI AI 1,2,4-TRIAZOLULUI ÎN BAZA N-[4-(3-METIL-5-SULFANIL-4H-1,2,4-TRIAZOL-4-IL)FENIL]ACETAMIDEI

Roman RUSNAC, Olga GARBUZ, Nicanor BARBĂ, Aurelian GULEA, Greta BĂLAN*, Olga BRUDUNIUC** Universitatea de Stat din Moldova *Universitatea de Stat de Medicină și Farmacie „N.Testemițanu” **Agenția Națională pentru Sănătate Publică

Abstract

SYNTHESIS OF DERIVATIVES OF 1,2,4-TRIAZOL BASED ON N-[4-(3-METHYL-5-SULFANYL-4H-1,2,4-TRIAZOL-4-YL)PHENYL]ACETAMIDE 

The article describes the synthesis methods of 8 organic compounds from the 1,2,4-triazole-3-thiol series, of which 7 compounds are new. The structure of compounds was confirmed by spectral methods: 1H-NMR, 13C -RMN and IR (FTIR). The triazoles (2) and (3) were investigated by X-ray diffraction on monocrystal. Some compounds have demonstrated moderate antiproliferative properties, in growth of HEp-2 and BxPC-3 cells. Antifungal activity is characteristic far compounds (2) and (7) with a MIC of 0.125 μg/mL. Antioxidative properties were studied using the ABTS and DPPH method where the best one was found to be 2-[(2-hydroxyphenyl)methylidene]-N-[4-(3-methyl-5- sulfanyl-4-triazol-4-yl)phenyl]hydrazine-1-carbothioamide (7). 

Keywords: 1,2,4-triazole, thiosemicarbazones, anticancer, antioxidant, N-phenyl-acetamide.