COMPUȘII COORDINATIVI AI UNOR BIOMETALE CU LIGANZII ÎN BAZA TIOSEMICARBAZONELOR CE CONȚIN 4-AMINOBENZOAT DE ETIL

Anna RUSNAC Universitatea de Stat din Moldova

Abstract

COORDINATION COMPOUNDS WITH SOME BIOMETHALS IN THE BASE OF TIOSEMICARBAZONES CONTAINING 4-ETHYL AMINOBENZOATE 

This paper presents the study of the specialized literature on the synthesis and biological properties of the coordinating compounds of some 3d metals based on 4-aryl thiosemicarbazones. According to the specialized literature there are only one thiosemicarbazone of 2-acetylpyridine based on 4-ethyl aminobenzoate. Coordination compounds of 3d metals with 4-aryl thiosemicarbazones possess a wide range of biological activities, such as: antibacterial, antifungal, antiviral, antimalarial, antitumor. Coordination compounds described in this paper have an increased inhibition capacity at the level of nanomolar concentrations (IC50= 0.01 - 0.001 μM) that exceeds tens and hundreds of times the antitumor activity, for example, of doxorubicin. 

Keywords: 4-ethyl aminobenzoate, thiosemicarbazones, coordination compounds, structure, biological activity