SINTEZA ȘI PROPRIETĂȚILE ANTIBACTERIENE ȘI ANTIFUNGICE ALE COMPUȘILOR COORDINATIVI AI Fe(III) CU 4-CICLOHEXILTIOSEMICARBAZONA 4-BENZOIL-3-METIL-1-FENIL-2-PIRAZOLIN-5-ONĂ

Roman RUSNAC, Maria BÎRCĂ, Sergiu ȘOVA, Aliona COTOVAIA, Greta BALAN,, Olga BURDUNIUC,, Aurelian GULEA Universitatea de Stat din Moldova Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu” Agenția Națională pentru Sănătate Publică

Abstract

SYNTHESIS AND ANTIMICROBIAL, ANTIFUNGAL PROPERTIES OF THE  COORDINATION  COMPOUNDS OF Fe (III) WITH 4-CYCLOHEXYLTIOSEMICARBAZONE 4-BENZOYL-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE 

In this paper the method of synthesis of three new coordination compounds of Fe(III) with 4-cyclohexylthiosemicar-bazone 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one is reported. The antimicrobial activity of compounds is moderate. The coordination compound [Fe(HL)2]NO3·H2O demonstrated the best activity against the fungal strain Cryptococcus neoformans. Therefore, the activity of this compound is 36 times better compared to nystatin; 18 and 2 times better than miconasol and fluconazole, respectively, antimicrobials currently used in the prophylaxis and treatment of infections caused by these microorganisms. 

Keywords: coordination compounds, 4-cyclohexylthiosemicarbazone, pyrazole, antimicrobial, antifungal.