SINTEZA, PROPRIETĂŢILE FIZICO-CHIMICE, ANTIOXIDATIVE ȘI ANTITUBERCULOASE ALE COMPUȘILOR COORDINATIVI AI UNOR METALE 3D CU IZONICOTINOILHIDRAZONA 2-HIDROXI-3-METOXIBENZALDEHIDA: Maria BÎRCĂ, Aliona COTOVAIA, Victor ȚAPCOV, Olga GARBUZ, Valeriu CRUDU*, Aurelian GULEA Universitatea de Stat din Moldova *Institutul de Ftiziopneumologie „Chiril Draganiuc”

USM ADMIN

SINTEZA, PROPRIETĂŢILE FIZICO-CHIMICE, ANTIOXIDATIVE ȘI ANTITUBERCULOASE ALE COMPUȘILOR COORDINATIVI AI UNOR METALE 3D CU IZONICOTINOILHIDRAZONA 2-HIDROXI-3-METOXIBENZALDEHIDA

Maria BÎRCĂ, Aliona COTOVAIA, Victor ȚAPCOV, Olga GARBUZ, Valeriu CRUDU, Aurelian GULEA Universitatea de Stat din Moldova Institutul de Ftiziopneumologie „Chiril Draganiuc”

Authors

USM ADMIN

Abstract

SYNTHESIS, PHYSICO-CHEMICAL, ANTIOXIDATIVE AND ANTITUBERCULOSIS PROPERTIES OF COORDINATION COMPOUNDS OF SOME 3D METALS WITH IZONICOTINOILHYDRAZONE OF 2-HYDROXY-3-METHOXYBENZALDEHYDE

The paper reveals the synthesis and investigation of antituberculosis properties and antioxidant activity of 13 new coordination compounds of Cr3 +, Mn2 +, Fe3 +, Co3 +, Ni2 +, Cu2 +, Zn2 + with isonicotinoyl hydrazone of 2-hydroxy-3-methoxybenzaldehyde (H2L). The ligand (H2L) was obtained by condensing isonicotinic hydrazide with 2-hydroxy-3-methoxybenzaldehyde. The structure of the ligand was determined by single crystal X-ray diffraction. The considered compounds display high antituberculosis and antioxidant activities.

Keywords: coordination compounds, antituberculosis activity, antioxidant activity, 3d metals, isonicotinoyl hydrazone of 2-hydroxy-3-methoxybenzaldehyde