СИНТЕЗ И БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ СМЕШАННОЛИГАНДНЫХ КООРДИНАЦИОННЫХ СОЕДИНЕНИЙ МЕДИ(II) C 4-АЛЛИЛТИОСЕМИКАРБАЗОНАМИ ЗАМЕЩЕННЫХ САЛИЦИЛОВОГО АЛЬДЕГИДА

Янина УЛЬКИНА, Василий ГРАУР, Аурелиан ГУЛЯ Молдавский государственный университет

Abstract

SYNTHESIS AND BIOLOGICAL ACTIVITY OF MIXED LIGAND COPPER(II) COORDINATION COMPOUNDS WITH 4-ALYLTIOSEMICARBASONES OF SUBSTITUTED SALICYLALDEHYDE

The paper presents the synthesis of the 2,4-dihydroxybenzaldehyde (H2L1) and 3,5-dibromosalicyl aldehyde (H2L2) 4-allylthosemicarbazones and six coordination compounds of copper with these ligands and heteroaromatic amines. The newly obtained compounds were investigated by elemental analysis, IR spectroscopy and molar electric conductibility. For the synthesized compounds, the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Bacillus cereus (ATCC 11778), Bacillus subtilis (ATCC 6633) and Candida albicans (ATCC 10231). Copper compounds and compounds with heteroaromatic amines showed a higher activity compared to the initial thiosemicarbazones. Keywords: coordination compounds; 2,4-dihydroxybenzaldehyde; 3,5-dibromosalicylic aldehyde; thiosemicarbazone; antibacterial, antifungal activity.