SOME INORGANIC AND ORGANIC BIOLOGICAL AGENTS

Olga GARBUZ * ,**, Ion TODERAS *, Nadejda RAILEAN *, Victor TAPCOV **, Aurelian GULEA ** *Institute of Zoology **Moldova State University

Abstract

Based on the known methods and their modifications, 3 compounds were synthesized: 2-formylpyridine N(4)-phenylthiosemicarbazone, complex copper(II) [Cu(L)Cl] with 2-formylpyridine N(4)-phenylthiosemicarbazone ligand, copper(II) mixed-ligand complex chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1- sulfonamide)copper [Cu(Str)(L)Cl]. The antiproliferative properties of these compounds towards cancer cell lines MeW-164 and HeLa have been investigated. The tested compounds demonstrated antiproliferative and selective activity towards cancer cells. The tested compounds inhibit the activity of LOX. Direct toxic evaluation of compounds was performed by Daphnia magna bioassay. It was found that the tested compounds have a lower toxicity than DOXO. Theoretical pharmacokinetics (Lipinski's rule, PSA) of CMT-22, CMT-67 and CMT-68 supports further in vivo studies. Keywords: anticancer compound, DNA fragmentation, apoptosis, antilipoxygenase activity, Lipinski’s rule