SYNTHESIS OF NEW bis-THIOSEMICARBAZONES BASED ON 2,2’-[PROPANE-1,3-DIIL-bis-(OXI)]DIBENZALDEHYDE WITH BIOLOGICAL POTENTIAL
Andrei CIURSIN, Roman RUSNAC, Aurelian GULEA, Moldova State University
Abstract
Cancer is the second most common cause of death. No known drug meets 100% the needs of the medical industry. For these reasons, many researchers are trying to synthesize new molecules with anti-cancer properties. A class
of organic compounds called thiosemicarbazones exhibit a broad spectrum of useful biological activities including
anticancer and antimicrobial. One of the possible mechanisms of the anticancer action of thiosemicarbazones is
the inhibition of topoisomerase IIα. In this article the synthetic procedure of some novel bis-thiosemicarbazones is
described. Their topoisomerase IIα inhibition potential was estimated by Molecular Docking method.
Keywords: bis-thiosemicarbazones, topoisomerase II inhibitors, anticancer activity, molecular docking.
