SYNTHESIS, ANTIOXIDANT ACTIVITY AND ADME ANALYSIS OF SOME N4-SUBSTITUTED THIOSEMICARBAZONES WITH β–IONONE FRAGMENT

Andrei CIURSIN, Iana STOICA, Roman RUSNAC, Aurelian GULEA, Laboratory of Advanced Materials in Biopharmaceutics and Technics, Institute of Chemistry, Moldova State University

Abstract

Thiosemicarbazones are organic compounds with remarkable biological properties, including anticancer, antibiotic, antifungal, and antioxidant effects. Some of these compounds have found application in medicine and are currently in use or undergoing clinical trials. One of the key problems in the application of chemical compounds, including thiosemicarbazones, in medical practice is their toxicity. A possible solution to this problem may be the synthesis of thiosemicarbazones based on natural fragments, which may lead to improved biological properties and reduced toxicity. In this work, four thiosemicarbazones were synthesized based on β-ionone. DPPH radical inhibition analysis was performed to reveal the antioxidant potential of the synthesized compounds. In addition, ADME (absorption, distribution, metabolism, and excretion) screening was performed to identify key pharmacological parameters essential for the potential use of these compounds in the medicinal field.

Keywords: thiosemicarbazones, antioxidant activity, DPPH, β-ionone, ADME screening.

DOI:https://doi.org/10.59295/sum6(186)2025_33