THE IMPACT OF THYROID DYSFUNCTION ON HEMATOLOGICAL HOMEOSTASIS

Iurie BACALOV, Adriana DRUȚA, Anastasia SULA, Universitatea de Stat din Moldova

Abstract

The present study aimed to evaluate changes in hematological indices in patients with thyroid dysfunction (hypothy-roidism and hyperthyroidism) compared with euthyroid individuals. A total of 42 patients were analyzed, in whom serumlevels of T3, T4, and TSH were determined, along with hematological parameters such as erythrocyte count, leukocytecount, hemoglobin concentration, and erythrocyte sedimentation rate (ESR). The results showed that hypothyroidismwas associated with a significant decrease in erythrocytes, leukocytes, and hemoglobin levels, accompanied by an in-crease in ESR, suggesting the presence of normochromic, normocytic anemia. In hyperthyroidism, T3 and T4 levelswere increased by up to 179%, while TSH levels were reduced by approximately 94%, indicating intensified metabolicactivity and hematological imbalance. Correlation analyses highlighted the direct influence of thyroid hormones onhematopoiesis, particularly through the modulation of erythropoietin. The study emphasized that the analysis of hema-tological indices represents a useful tool in the monitoring of patients with thyroid function disorders.Keywords: hypothyroidism, hyperthyroidism, hematological indices, thyroxine, triiodothyronine, TSH.

DOI: https://doi.org/10.59295/sum1(191)2026_5