SYNTHESIS, STRUCTURE AND BIOLOGICAL ACTIVITY OF N(4)-ALLYL-3-THIOSEMICARBAZONES AND THEIR COORDINATION COMPOUNDS WITH SOME 3D METALS

Vasilii GRAUR Moldova State University

Abstract

The paper presents a review of different N(4)-allyl-3-thiosemicarbazones and their coordination compounds described in literature. N(4)-allyl-3-thiosemicarbazide can form corresponding thiosemicarbazones with aliphatic, aromatic and heteroaromatic carbonyl compounds. In the presence of transitional metal ions they can form coordination compounds of different structures. Both coordination compounds and proligands manifest antitumor, antibacterial, antiviral, and antimalarial activities. Copper(II) coordination compounds with these ligands manifest better antitumor activity than corresponding proligands. Keywords: N(4)-allyl-3-thiosemicarbazone, complexes, biological activity.