GLOBULINELE DE REZERVĂ 11S DIN SEMINŢE CA ALERGENI

Ala CHERDIVARĂ, Angela RUDACOVA, Andrei ŞUTOV Universitatea de Stat din Moldova

Abstract

SEED STORAGE 11S GLOBULINS AS ALLERGENS

Storage proteins in seeds of several plants are allergens. The proteins from peanut seeds, including storage 11S globulin Ara h3, are of the highest allergenicity. Among seed 11S globulins, a relatively high allergenicity in addition to Ara h 3 is characteristic of subunits Gly m G1, Gly m G2 and Gly m G3 of soybean 11S globulin. A partial matching of positions of antigen determinants (IgE epitopes) in amino acid sequences of Ara h 3 and soybean 11S globulin subunits was shown. Possible ways for reducing of the allergenicity of 11S globulins from the seeds of soybean and other plants is discussed. Keywords: seed storage 11S globulins, allergens, IgE epitopes, peanut, soybean.