GLOBULINELE DE REZERVĂ 7S DIN SEMINŢE CA ALERGENI. IMUNOREACTIVITATEA ÎNCRUCIŞATĂ ÎNTRE GLOBULINELE DE REZERVĂ 7S ŞI 11S

Ala CHERDIVARĂ, Angela RUDAKOV, Andrei ŞUTOV Universitatea de Stat din Moldova

Abstract

SEED STORAGE 7S GLOBULINS AS ALLERGENS. CROSS IMMUNOREACTIVITY BETWEEN STORAGE 7S AND 11S GLOBULINS

Among seed storage proteins, the peanut 7S globulin Ara h1 exhibits a highest allergenicity. Multiple antigen determinants (IgE epitopes) have been identified inside the Ara h1 amino acid sequence. The presence of potential IgE epitopes inside structurally equivalent homologous sequence regions of 7S globulins from other plants (mainly from soybeans) was shown. Probable existence of a cross-immunoreactivity between Ara h1 and the subunits of soybean 11S globulin Gly m G5 was demonstrated. Keywords: seed storage globulins, allergens, IgE epitopes, peanut, soybeans.