SINTEZA ȘI STUDIUL UNOR N'-(n-DIMETILFENIL)-N,N-DIMETILTIOUREI ȘI N(4)-n-DIMETILFENIL-TIOSEMICARBAZIDE

Tatiana ERHAN, Olga GARBUZ, Aurelian GULEA Universitatea de Stat din Moldova

Abstract

THE SYNTHESIS AND STUDIES OF THE SOME N'-(n-DIMETHYLPHENYL)-N,N DIMETHYLTHIOUREAS AND N (4)-n-DIMETHYLPHENYL-3-THIOSEMICARBAZIDES 

The present paper describes the synthesis of 6 new thiosemicarbazides and 6 thioureas. The identity and purity of obtained organic compounds was proved by chromatography TSS, melting points, as well as by 13C and 1H NMR, IR spectra. The synthesized substances were tested, in vitro for the antiproliferative activity on cancer and normal cells of: HeLa (cervical cancer) cells, BxPc-3 (pancreatic cancer) cells, RD (rhabdomyosarcoma) cells and on normal MDCK cells. Structure-activity relationships were carried out. 

Keywords: N (4)-n-dimethylphenyl-3-thiosemicarbazide, N'-(n-dimethylphenyl)-N,N-dimethylthiourea, antiproliferative activity, HeLa, BxPc-3, RD, MDCK