SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF COPPER(II), NICKEL(II), COBALT(III) AND IRON(III) COORDINATION COMPOUNDS WITH 1-(2-HYDROXYPHENYL)ETHANONE N(4)-ALLYL-S-METHYLISOTHIOSEMICARBAZONE

Irina USATAIA State University of Moldova

Abstract

The paper presents the synthesis of the 1-(2-hydroxyphenyl)ethanone N(4)-allyl-S-methylisothiosemicarbazone (HL) and seven coordination compounds of copper, nickel, cobalt and iron with this pro-ligand. The newly obtained compounds were investigated by IR, 1H and 13C NMR spectroscopy, elemental analysis, molar electric conductibility and magnetic susceptibility. For the synthesized compounds the antibacterial and antifungal activities in vitro were studied on a series of standard strains, such as Staphylococcus aureus (ATCC 25923), Escherihia coli (ATCC 25922), Klebsiella pneumonae and Candida albicans. The in vitro antiproliferative activity of the pro-ligand and complexes was screened on Hep-2, BxPC-3, RD cancer cells and normal MDCK cells. It was established that coordination compounds manifest better antiproliferative activity than the pro-ligand. 

Keywords: coordination compounds, 1-(2-hydroxyphenyl)ethanone, isothiosemicarbazone, biological activity.