EVALUAREA BIOLOGICĂ A COMPUȘI LOR COORDINATIVI AI CUPRULUI(II) CU UNELE TIOSEMICARBAZONE HETEROCICLICE

Olga GARBUZ*,** , Nadejda RAILEAN*,** , Igor GOSTEV* , Anna RUSNAC**, Ion TODERAȘ* , Aurelian GULEA** * Institutul de Zoologie **Universitatea de Stat din Moldova

Аннотация

BIOLOGICAL EVALUATION OF COPPER(II) COMPLEXES WITH SOME HETEROCYCLIC THIOSEMICARBAZONES Three new compounds were synthesized: thiosemicarbazone 2-acetylpyridine H2L, chlor (thiosemicarbazone 2- acetylpyridine) dicopper(II) (1) and (thiosemicarbazone 2-acetylpyridine) dicopper(II) nitrate (2) which potentially possesses antiproliferative properties toward cancer cells. Doxorubicin (7-[4-amino-5-hydroxi-6-methyloxan-2-il]oxi- 6,9,11-trihydroxi-9-(2-hydroxiacetyl)-4-metoxi-8,10-dihydro-7H-tetracen-5,12-dion) was used as the reference anticancer compound and Trolox (acid 6-hydroxi-2,5,7,8-tetramethilcroman-2-carboxilic) was used as the reference antioxidant compound. The tested compounds demonstrated a high antioxidant effect against ABTS•+ radical cations than interaction with Trolox. The tested compounds showed general toxicity on Daphnia magna after 24 hours of exposure with a determination of decreasing string. The experimental data indicated the prospects for further search for selective anticancer substances with high antioxidant activity and low toxicity among tested compounds. Keywords: antioxidant activity, ABTS radical cation, Trolox, thiosemicarbazone, toxicity, Daphnia magna, Doxorubicin.