SYNTHESIS OF WATER-SOLUBLE ANALOGS-POLYMERS OF POLY-N-VINYLPYROLIDONE GRAFTED WITH ZINC PHTHALOCYANINE
Stefan ROBU, Tamara POTLOG, Ion LUNGU, Petru BULMAGA Universitatea de Stat din Moldova Pavel TIULEANU Universitatea de Chimie Tehnologică „D. I. Mendeleev”, Moscova, Rusia Viorel PRISACARI, Veronica SAVA Universitatea de Stat de Medicină și Farmacie „N. Testemițeanu
Аннотация
The paper describes the synthesis of polymer analogues of N-vinylpyrrolidone with acryloyl chloride functio-
nalized with zinc phthalocyanine, by using the Friedel-Crafts method. The grafting of zinc phthalocyanine to N- vinylpyrrolidone copolymers was carried out at low temperatures (3-5 0C), using the anhydrous AlCl3 catalyst. The purification of the new polymers was carried out by sedimentation in water. The chemical structure of polymer ana- logues were performed by IR, UV/Vis spectroscopy. The bactericidal properties of the synthesized polymer analogs were studied. The antibacterial activity of grafted copolymers with zinc phthalocyanine was performed „in vitro”, with a series of bactericidal cultures such as S. Aureus, E. Coli, Ps. Aeruginosa and others. It has been shown that the obtained polymer analogs possess relatively high bactericidal activity against some cultures such as Ps. Aeruginosa, Pr. Vulgaris to the action of furacilin or chlorhexidines, used as controls.
Keywords: zinc phthalocyanine, N-vinylpyrrolidone, acryloyl chloride, light absorption, bactericidal properties, bactericidal cultures.
