EXPLORING THE ANTIOXIDANT ACTIVITY OF 1-(PIPERIDIN-1-YL) PROPANE-1,2-DIONE 4-PHENYLTHIOSEMICARBAZONE AND 3d METAL COORDINATION COMPOUNDS WITH THIS LIGAND
Ianina GRAUR, Mihail MAXIM, Vasilii GRAUR, Victor TSAPKOV, Aurelian GULEA, Laboratory of Advanced Materials in Biopharmaceutics, Institute of Chemistry, Moldova State University Olga GARBUZ, Laboratory of Systematics and Molecular Phylogenetics, Institute of Zoology, Moldova State University
Аннотация
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The new 1-(piperidin-1-yl)propane-1,2-dione 4-phenylthiosemicarbazone (HL) and its 7 coordination compounds
[Cu(L)X] (X = Br- (I); Cl- (II); NO3- (III); CH3COO- (IV); Cl2CHCOO- (V)), [Co(L)2]NO3 (VI), [Fe(L)2]NO3 (VII)
have been synthesized and characterized by elemental analysis, FTIR, 1H, 13C NMR spectra and molar electric
conductibility. For the obtained compounds it was studied the antioxidant activity towards ABTS•+ radical cation.
Uncoordinated 4-phenylthiosemicarbazone HL is the most active one with IC50 14.1 μM. Its activity is higher than
that of Trolox which is used in medicine as an antioxidant. Among all the synthesized coordination compounds, the
iron(III) complex VII showed the greatest activity. The antioxidant activity of metal complexes is influenced by the
anion and the nature of the central metal atom.
Keywords: coordination compounds, 4-phenylthiosemicarbazone, pyruvamide, antioxidant activity
