IMPACT OF GUT DYSBIOSIS ON COENZYME Q10 LEVELS

Camelia RÂTEA, Mitogenix Innovations - Centrul de nutritie clinică de regenerare mitocondrială, Universitatea de Stat din Moldova Adriana-Daniela SOCIANU, Mitogenix Innovations - Centrul de nutritie clinică de regenerare mitocondrială, Universitatea de Medicină, Farmacie, Științe și Tehnologie ,,George Emil Palade” din Târgu-Mureș Septimiu Toader VOIDĂZAN, Universitatea de Medicină, Farmacie, Științe și Tehnologie ,,George Emil Palade” din Târgu-Mureș

Аннотация

Thisstudyinvestigatestherelationshipbetween intestinal dysbiosisandcoenzyme Q10 deficiency in a group of 13
patients. The resultsindicatedthatallparticipantsexhibited a coenzyme Q10 deficiency, associatedwithimbalances in
intestinal microbiota, elevated fecal pH, and a highmicrobialload, particularly for pathogenicspeciessuch as Candida
albicans. Thesechangessuggestthatdysbiosismayaffecttheabsorptionandutilization of coenzyme Q10, reducing metabolic efficiencyandpromoting oxidative stress.
The studyhighlightsthecritical role of a balancedmicrobiota in maintaining optimal coenzyme Q10 levels, essential for mitochondrialand antioxidant health. Conclusionsrecommenddietaryandprobioticinterventionstorestoremicrobioticbalance, aimingtoimprovecoenzyme Q10 absorptionandsupportthebody’senergyandimmunefunctions.
Thesefindingsunderscoretheimportance of monitoring andoptimizing intestinal health in managingcoenzyme Q10
deficiencies.
Keywords: coenzyme Q10, mitochondrialdysfunction, intestinal dysbiosis, intestinal permeability, oxidative
stress, microbiota, energy metabolism.

DOI: https://doi.org/10.59295/sum6(176)2024_23