SINTEZA, STRUCTURA ȘI PROPRIETĂȚILE COMPUȘILOR COORDINATIVI AI CUPRULUI(II) CU DERIVAȚII TIOSEMICARBAZONEI 8-FORMILCHINOLINEI

Elena STRATULAT, Sergiu ȘOVA, Viorel PRISACARI*, Ana DIZDARI*, Ion CORJA, Aurel PUI**, Oleg PALAMARCIUC Universitatea de Stat din Moldova *Universitatea de Stat de Medicină şi Farmacie „Nicolae Testemiţanu” **Universitatea „Alexandru Ioan Cuza” din Iași

Аннотация

SYNTHESIS, STRUCTURE AND PROPERTIES OF COPPER(II) COORDINATION COMPOUNDS WITH 8-FORMILQUINOLINE THIOSEMICARBAZONE DERIVATIVES

In this study we show the synthesis and crystallographic investigation of Cu(II) coordination compounds with 8-formyl-quinoline thiosemicarbazone. In dilute solutions the copper ions react with organic reagents at room temperature to form 1:1 = metal:ligand yellow coloured complexes. Complex of copper(II) with 8-formylquinoline 4-phenylthiosemi-carbazone in aqueous ethanol solution is characterized by a maximum absorption located at λ=390 nm. The calibration curve has a linear character in the range of copper concentrations 2.5∙10-6 ÷ 4∙10-5 M. The 8-formylquinoline 4-phenyl-thiosemicarbazonev is proposed for the spectrophotometric determination of copper(II) ions in solution. The method has been successfully applied for the determination of copper when the yield of coordination reactions with organic ligands is small. Compound [CuLAc] exhibiting antibacterial activity against Staphylococcus aureus (strain 209-P), Entrecoccus faecalis and Proteus vulgaris bacteria.

Keywords: coordination compound, copper(II), thiosemicarbazones, biological activity, optical properties.